Using Rexulti in the last trimester of pregnancy may cause muscle movement problems, medicine withdrawal symptoms, or both of these in your newborn. If you become pregnant while taking Rexulti, talk to your healthcare provider about registering with the National Pregnancy Registry for Atypical Antipsychotics .* REXULTI may be administered without dosage adjustment in patients with MDD when administered with strong CYP2D6 inhibitors (e.g., paroxetine, fluoxetine). ----- USE IN SPECIFIC POPULATIONS ----- Pregnancy: May cause extrapyramidal and/or withdrawal symptoms in neonates with third trimester exposure (8.1) SeeAug 18, 2023 · In trials, the antipsychotic drug brexpiprazole (Rexulti) failed to provide a clinically meaningful benefit and increased the risk of death. Yet the US Food and Drug Administration (FDA) has fast ... For years you diligently contributed to your 401K retirement plan. But now, you’re coming closer to the time when you need to consider your 401K’s withdrawal rules. There are also ...The FDA just approved Rexulti to treat agitation caused by dementia in Alzheimer’s patients. Rexulti is an existing medication that was approved to treat severe depression and schizophrenia in 2015. The drug costs about $1,400 per month without insurance or various discounts, but a generic and more affordable version may soon be …15 Aug 2017 ... ... withdrawal) and general symptoms (e.g. anxiety, depression). In one trial, mean improvements in the PANSS scores after treatment were ...Applies to: metoclopramide and Rexulti (brexpiprazole) Using metoclopramide together with brexpiprazole is not recommended. Treatment with either medication alone can cause Parkinson-like symptoms and abnormal muscle movements, and combining them may increase that risk. The most serious of the movement disorders associated with the use … think you are pregnant during treatment with REXULTI. are pregnant or plan to become pregnant. REXULTI may harm your unborn baby. Taking REXULTI during your third trimester of pregnancy may cause your baby to have abnormal muscle movements or withdrawal symptoms after birth. ¥ ¥ have or have had a low white blood cell count Recommended target dose: 2-4 mg once daily. Titrate to 2 mg once daily on Day 5 through Day 7, then to 4 mg on Day 8 based on patient's clinical response & tolerability. Max: 4 mg daily. Moderate to severe hepatic impairment (Child-Pugh score ≥7); moderate, severe or end-stage renal impairment (CrCl <60 mL/min) Max: 2 mg once daily for ... The effectiveness of Rexulti for the treatment of agitation associated with dementia due to Alzheimer’s disease was determined through two 12-week, randomized, double-blind, placebo-controlled ...frequency of symptoms. *REXULTI was studied in two 12-week clinical trials with patients aged 51-90 with agitation that may happen with dementia due to Alzheimer’s disease. At the end of the 12 weeks, patients who took REXULTI experienced a greater improvement in their symptoms of agitation compared to those who took a placebo.Provides for the use of REXULTI (brexpiprazole) 0.25 mg, 0.5 mg, 1 mg, 2 mg, 3 mg, and 4 mg Tablets for the ... 2928-1 A placebo-controlled, randomized withdrawal maintenance study of brexpiprazole in patients who require adjunctive treatment of major depressive disorder. Final Protocol Submission: 03/2016 .The FDA just approved Rexulti to treat agitation caused by dementia in Alzheimer’s patients. Rexulti is an existing medication that was approved to treat severe depression and schizophrenia in 2015. The drug costs about $1,400 per month without insurance or various discounts, but a generic and more affordable version may soon be …For years you diligently contributed to your 401K retirement plan. But now, you’re coming closer to the time when you need to consider your 401K’s withdrawal rules. There are also ...third trimester of pregnancy may cause your baby to have abnormal muscle movements or withdrawal symptoms after birth. oTell your healthcare provider if you become pregnant or think you are pregnant during treatment with REXULTI. oIf you become pregnant during treatment with REXULTI, talk to your healthcare provider about registering with17 Jun 2022 ... ... withdrawal, lack of energy, emotion, and ... symptoms, hyperprolactinemia, and worsening negative and cognitive symptoms. ... Rexulti (package ...brexpiprazole food. Applies to: Rexulti (brexpiprazole) Alcohol can increase the nervous system side effects of brexpiprazole such as dizziness, drowsiness, and difficulty concentrating. Some people may also experience impairment in thinking and judgment. You should avoid or limit the use of alcohol while being treated with brexpiprazole.are pregnant or plan to become pregnant. REXULTI may harm your unborn baby. Taking REXULTI during your third trimester of pregnancy may cause your baby to have abnormal muscle movements or withdrawal symptoms after birth. Talk to your healthcare provider about the risk to your unborn baby if you take REXULTI during pregnancy.Total spending for April was $191.4 million, up from a healthy $188 million in March. (DeepIntent Inc) Otsuka and Lundbeck’s atypical antipsychotic Rexulti has taken …Rexulti (brexpiprazole) 0.5 mg to 4 mg ... Possible increase in symptoms leading to potential. Use of seclusion or restraint. ... Do not suddenly stop taking this medication as it could lead to symptoms of withdrawal. Talk with your doctor before stopping this medication, and they can help you find a plan that works for you. ...Taking REXULTI during your third trimester of pregnancy may cause your baby to have abnormal muscle movements or withdrawal symptoms after birth. ... At the end of 6 weeks, some patients who took REXULTI saw a reduction in their symptoms of schizophrenia. Start the conversation with your doctor about REXULTI. Get the Doctor Discussion Guide ...These are some of the most common side effects you may feel: anxiety, brain zaps, depression, dizziness, fatigue, headaches, insomnia, nausea/vomiting, and a …Rexulti (brexpiprazole) is a prescription drug that helps treat certain mental health conditions, including depression. This drug can interact with alcohol and other medications. For example ... Recommended target dose: 2-4 mg once daily. Titrate to 2 mg once daily on Day 5 through Day 7, then to 4 mg on Day 8 based on patient's clinical response & tolerability. Max: 4 mg daily. Moderate to severe hepatic impairment (Child-Pugh score ≥7); moderate, severe or end-stage renal impairment (CrCl <60 mL/min) Max: 2 mg once daily for ... Rexulti Savings Card. Eligible commercially insured patients pay $0 for the first 2 monthly fills then pay $5 per fill; maximum savings per fill is $1200 with an annual program savings of $8180; offer valid for 12 uses per year; for additional information contact the program at 844-415-0674. Applies to: Rexulti Number of uses: 12 fills per year REXULTI works with your antidepressant to help build on the progress you've already made. 6-week study in adults, with ongoing symptoms of depression, still taking an antidepressant. Individual results may vary. When taken with an antidepressant, * REXULTI was proven to significantly reduce depression symptoms more than the antidepressant alone.Rexulti helps stabilize mood and alleviate extreme highs or lows. People may experience emotional balance and improved well-being or notice a reduction in specific symptoms. It’s important to communicate changes in how one feels to their healthcare provider for optimal results. 2.The most common side effects of taking Rexulti are weight gain, sleepiness, dizziness, cold symptoms, and restlessness. Some side effects, such as headaches or gastrointestinal issues, might go ...Rexulti has an average rating of 6.4 out of 10 from a total of 452 ratings on Drugs.com. 52% of reviewers reported a positive effect, while 27% reported a negative effect. Trintellix has an average rating of 6.0 out of 10 from a total of 1099 ratings on Drugs.com. 48% of reviewers reported a positive effect, while 33% reported a negative effectMax: 4 mg daily. Maintenance dose range: 2-4 mg daily. Adjunctive treatment of MDD Initially 0.5 or 1 mg once daily. Titrate to 1 mg daily & up to target dose of 2 mg daily at intervals of up to 1 wk. Moderate to severe hepatic impairment (Child-Pugh score ≥7) & moderate, severe or end-stage renal impairment (CrCl <60 mL/min) Schizophrenia ...The purpose of a 401(k) plan is to set aside money for retirement, but if you have debts with high interest rates, you may be tempted to withdraw funds early to pay off the debt. W...In clinical studies, people taking Rexulti didn’t show withdrawal symptoms after stopping treatment.(Withdrawal symptoms are side effects that can occur when you stop taking a drug that your body has become dependent on.) This also suggests that Rexulti doesn’t cause physical dependence. (With dependence, your body needs the …Using Rexulti in the last trimester of pregnancy may cause muscle movement problems, medicine withdrawal symptoms, or both of these in your newborn. If you become pregnant while taking Rexulti, talk to your healthcare provider about registering with the National Pregnancy Registry for AtypicalAntipsychotics.May 18, 2023 · Rexulti (brexpiprazole) works by altering chemicals in the brain that can lead to schizophrenia or depression. Rexulti is an atypical antipsychotic medication approved to treat: schizophrenia; symptoms of depression (major depressive disorder) when used with other medicines; agitation associated with dementia due to Alzheimer’s disease. Rexulti has an average rating of 6.4 out of 10 from a total of 447 ratings on Drugs.com. 52% of reviewers reported a positive effect, while 28% reported a negative effect. Seroquel has an average rating of 7.0 out of 10 from a total of 676 ratings on Drugs.com. 60% of reviewers reported a positive effect, while 21% reported a negative effect.Rexulti. Warning. There may be a slightly increased risk of serious, possibly fatal side effects (such as stroke, heart failure, fast/irregular heartbeat, pneumonia) when this medication is used by older adults with dementia. ... other mental/mood symptoms, or suicidal thoughts/attempts. It is very important to talk with the doctor about the ...At a cost of around $1,400 a month Rexulti's makers, Otsuka and Lundbeck, are forecasting an additional $1 billion in annual sales, but there are serious questions about the harm-benefit balance ...frequency of symptoms. *REXULTI was studied in two 12-week clinical trials with patients aged 51-90 with agitation that may happen with dementia due to Alzheimer’s disease. At the end of the 12 weeks, patients who took REXULTI experienced a greater improvement in their symptoms of agitation compared to those who took a placebo.Side effects. Dosage. How to take. Rexulti vs. Abilify. FAQ. Use for depression. Use for other conditions. Cost. What to consider. Rexulti vs. Latuda. …Over 6 million total prescriptions in the US1. For adult patients with. MDD on an ADT, Add REXULTI® (brexpiprazole) for antidepressant symptom response. A 6-week, double-blind, placebo-controlled, fixed-dose pivotal trial studied mean change from baseline (SE) in MÅDRS total score at 6 weeks (-8.4 [0.6] for ADT + REXULTI [n=175] vs -5.2 [0.6 ...These are some of the most common side effects you may feel: anxiety, brain zaps, depression, dizziness, fatigue, headaches, insomnia, nausea/vomiting, and a …think you are pregnant during treatment with REXULTI. are pregnant or plan to become pregnant. REXULTI may harm your unborn baby. Taking REXULTI during your third trimester of pregnancy may cause your baby to have abnormal muscle movements or withdrawal symptoms after birth. • • have or have had a low white blood cell count The half life of Rexulti is 2 weeks, so I didn’t have any withdrawal symptoms until then. The majority of my symptoms were emotional/psych ones. These were my symptoms with the Rexulti: Mood swings and lots of crying, I felt very unstable. Depersonalization and derealization. Severe anxiety. Sydbank: Positivt Lundbeck-regnskab trods modvind til Rexulti. Rexulti, der behandler skizofreni og depression, underpræsterede ift. forventninger, men …What Are Side Effects of Rexulti? Rexulti may cause serious side effects including: trouble walking, difficulty speaking (and being understood), sudden weakness on one side of the body, vision …Rexulti Savings Card. Eligible commercially insured patients pay $0 for the first 2 monthly fills then pay $5 per fill; maximum savings per fill is $1200 with an annual program savings of $8180; offer valid for 12 uses per year; for additional information contact the program at 844-415-0674. Applies to: Rexulti Number of uses: 12 fills per yearThe U.S. Food and Drug Administration (FDA) this week approved the expanded use of Rexulti (brexpiprazole) for the treatment of agitation associated with dementia due to Alzheimer’s disease (AD). “Agitation associated with dementia due to Alzheimer’s disease is a common neuropsychiatric symptom that is reported in …Most individuals and businesses today have some type of banking account. Having a trusted financial service provider is important as it is a safe place to hold and withdraw earned ...REXULTI ® (REX-ul-TE) (brexpiprazole) tablets, for oral use ... visits as needed, especially if you have concerns about symptoms. ... third trimester of pregnancy may cause your baby to have abnormal muscle movements or withdrawal symptoms after birth. Talk to your healthcare provider about the risk to your unborn baby if you take REXULTI duringThe purpose of a 401(k) plan is to set aside money for retirement, but if you have debts with high interest rates, you may be tempted to withdraw funds early to pay off the debt. W...Call your healthcare provider or go to the nearest hospital emergency room right away if you have some or all of the following signs and symptoms of NMS: high fever; changes in …Taking REXULTI during your third trimester of pregnancy may cause your baby to have abnormal muscle movements or withdrawal symptoms after birth. Talk to your healthcare provider about the risk to your unborn baby if you take REXULTI during pregnancy.Recommended target dose: 2-4 mg once daily. Titrate to 2 mg once daily on Day 5 through Day 7, then to 4 mg on Day 8 based on patient's clinical response & tolerability. Max: 4 mg daily. Moderate to severe hepatic impairment (Child-Pugh score ≥7); moderate, severe or end-stage renal impairment (CrCl <60 mL/min) Max: 2 mg once daily for ...Symptoms of depression may last for 2 weeks or more, occurring nearly every day. These may include: A depressed mood most of the day (feeling sad, empty, hopeless, or on the verge of tears) Loss of interest or pleasure in activities you once enjoyed. Weight loss (even when not on a diet) or experiencing weight gain.Symptoms of depression may last for 2 weeks or more, occurring nearly every day. These may include: A depressed mood most of the day (feeling sad, empty, hopeless, or on the verge of tears) Loss of interest or pleasure in activities you once enjoyed. Weight loss (even when not on a diet) or experiencing weight gain.Rexulti - Get up-to-date information on Rexulti side effects, uses, dosage, overdose, pregnancy, alcohol and more. Learn more about Rexulti ... Rexulti is a prescription medication used to treat the symptoms of major depressive disorder (MDD) and schizophrenia in adults. It belongs to a group of drugs called atypical antipsychotics.For years you diligently contributed to your 401K retirement plan. But now, you’re coming closer to the time when you need to consider your 401K’s withdrawal rules. There are also ...Jun 15, 2023 · Neonates exposed to antipsychotic drugs, like Rexulti, during the third trimester of pregnancy are at risk for extrapyramidal and/or withdrawal symptoms. It is unknown if Rexulti passes into breast milk or if it would affect a nursing infant. Consult your doctor before breastfeeding. Additional Information *REXULTI may be administered without dosage adjustment in patients with MDD when administered with strong CYP2D6 inhibitors (e.g., paroxetine, fluoxetine).-----USE IN SPECIFIC POPULATIONS -----Pregnancy: May cause extrapyramidal and/or withdrawal symptoms in neonates with third trimester exposure (8.1)Withdrawal Symptoms. Some of the symptoms that you may experience when discontinuing antipsychotics are: Vomiting, nausea, and diarrhea; Difficulty sleeping, restlessness, anxiety, and agitation; Dizziness; Runny nose; Problems with muscle movement, including involuntary muscle contractions, inability to stay still, and uncontrollable movementsHowever, available data suggest that babies exposed to antipsychotics like Rexulti during the third trimester of pregnancy may be at risk of withdrawal symptoms and movement abnormalities when they are born. Sometimes these symptoms are mild and resolve over time without treatment, but in other cases babies may require prolonged …For your appropriate adult patients with MDD, consider REXULTI sample titration packs for adjunctive use with antidepressant therapy: 14-day titration pack: 7 days at 0.5 mg/day and 7 days at 1 mg/day. Single-dose packs: 0.5 mg, 1 mg, 2 mg, 3 mg. Sample packs are not for sale or reimbursement.*REXULTI may be administered without dosage adjustment in patients with MDD when administered with strong CYP2D6 inhibitors (e.g., paroxetine, fluoxetine).-----USE IN SPECIFIC POPULATIONS -----Pregnancy: May cause extrapyramidal and/or withdrawal symptoms in neonates with third trimester exposure (8.1)At a cost of around $1,400 a month Rexulti's makers, Otsuka and Lundbeck, are forecasting an additional $1 billion in annual sales, but there are serious questions about the harm-benefit balance ...think you are pregnant during treatment with REXULTI. are pregnant or plan to become pregnant. REXULTI may harm your unborn baby. Taking REXULTI during your third trimester of pregnancy may cause your baby to have abnormal muscle movements or withdrawal symptoms after birth. • • have or have had a low white blood cell countWithdrawal wasn’t reported in clinical trials of Rexulti. But withdrawal has been reported by people who abruptly stopped taking similar drugs, ... Withdrawal symptoms could include: sleep problems;Breastfeeding. Precautions. Expiration. Rexulti is a brand-name oral tablet that’s prescribed for certain conditions, such as depression. Rexulti contains the active …Side effects. FAQ. Dosage. Uses. Cost. How it works. Withdrawal and dependence. Rexulti and alcohol. Interactions. Alternatives. Overdose. How to take. …symptoms of an infection (e.g., sore throat, fever, chills, cough) symptoms of high blood sugar (excessive thirst or hunger, excessive urination, weight loss, tiredness) Stop taking the medication and seek immediate medical attention if any of the following occur: long-lasting (greater than 4 hours) and painful erection of the penis; seizuresRexulti did not cause withdrawal symptoms in clinical trials. But Rexulti belongs to a class of medications called atypical antipsychotics. And withdrawal has been reported in people who took ...Five studies with a total of 261 individuals were included. The primary outcome, proportion of individuals with withdrawal symptoms after antipsychotic discontinuation, was 0.53 (95% CI, 0.37–0.70; I2 = 82.98%, P < 0.01). An odds ratio of 7.97 (95% CI, 2.39–26.58; I2 = 82.7%, P = 0.003) and NNH of 3 was calculated for the …REXULTI is a drug for the treatment of major depressive disorder (MDD). In a patient who is already taking a medication for depression that is not adequately treating their symptoms, REXULTI can ...Rexulti (brexpiprazole) works by altering chemicals in the brain that can lead to schizophrenia or depression. Rexulti is an atypical antipsychotic medication approved to treat: schizophrenia; symptoms of depression (major depressive disorder) when used with other medicines; agitation associated with dementia due to Alzheimer’s disease.are pregnant or plan to become pregnant. REXULTI may harm your unborn baby. Taking REXULTI during your third trimester of pregnancy may cause your baby to have abnormal muscle movements or withdrawal symptoms after birth. Talk to your healthcare provider about the risk to your unborn baby if you take REXULTI during pregnancy.Withdrawal Symptoms. Some of the symptoms that you may experience when discontinuing antipsychotics are: Vomiting, nausea, and diarrhea; Difficulty sleeping, restlessness, anxiety, and agitation; Dizziness; Runny nose; Problems with muscle movement, including involuntary muscle contractions, inability to stay still, and uncontrollable movementsBreastfeeding. Precautions. Expiration. Rexulti is a brand-name oral tablet that’s prescribed for certain conditions, such as depression. Rexulti contains the active drug brexpiprazole and...Withdrawal symptoms could be more severe if Rexulti is stopped suddenly. You could also notice a return or worsening of your depression or schizophrenia symptoms. Withdrawal symptoms may...Provides for the use of REXULTI (brexpiprazole) 0.25 mg, 0.5 mg, 1 mg, 2 mg, 3 mg, and 4 mg Tablets for the ... 2928-1 A placebo-controlled, randomized withdrawal maintenance study of brexpiprazole in patients who require adjunctive treatment of major depressive disorder. Final Protocol Submission: 03/2016 .think you are pregnant during treatment with REXULTI. are pregnant or plan to become pregnant. REXULTI may harm your unborn baby. Taking REXULTI during your third trimester of pregnancy may cause your baby to have abnormal muscle movements or withdrawal symptoms after birth. • • have or have had a low white blood cell countRexulti’s withdrawal symptoms appear within the first few days of stopping or substantially reducing drug dosage. They tend to peak within a week from stopping the medication and start to ease after that. Always follow your doctors instructions for stopping a medication. It is recommended to gradually reduce dosages to avoid some withdrawal ...The FDA fast-tracked brexpiprazole (Rexulti) in May 2023. Rexulti is the first antipsychotic drug to treat agitation for dementia, but there are some risks associated with the drug.Tardive dyskinesia is possible while taking Rexulti. It involves involuntary, repetitive body movements. If you experience such symptoms while taking Rexulti, your doctor might consider stopping the medication. If you find yourself experiencing compulsive behaviors, like excessive gambling, while on Rexulti, talk to your healthcare provider.
6 Jun 2017 ... Research on treating bipolar disorder with Rexulti ... I still dealt with some manic symptoms and possible withdrawal because of the reduction of .... Gabriel from 90 day fiance
*REXULTI may be administered without dosage adjustment in patients with MDD when administered with strong CYP2D6 inhibitors (e.g., paroxetine, fluoxetine).-----USE IN SPECIFIC POPULATIONS -----Pregnancy: May cause extrapyramidal and/or withdrawal symptoms in neonates with third trimester exposure (8.1) The suggestion was to go on .5mg of Rexulti every night with his ropiniorole for restless leg syndrome and continue taking 40 mg of cymbalta for depression/anxiety in the morning. The result here was almost that of " 'roid rage" from steroids. The sub-vocalization, paranoia, and paralyzing fear were gone, but in their place was a growing lack ... Included below is a list of symptoms that you might experience following Rexulti withdrawal. Agitation: A symptom of Rexulti discontinuation that certain individuals might experience is agitation. Agitation is characterized by internal excitement, nervousness, or a stirring sensation.Rexulti helps stabilize mood and alleviate extreme highs or lows. People may experience emotional balance and improved well-being or notice a reduction in specific symptoms. It’s important to communicate changes in how one feels to their healthcare provider for optimal results. 2.10 Mar 2017 ... ... treatment withdrawal. A total of 29.5% of ... Rexulti® (brexpiprazole) [full prescribing information]. ... Adjunctive brexpiprazole (OPC-34712) in ...The NDC code 59148-035 is assigned by the FDA to the product Rexulti which is a human prescription drug product labeled by Otsuka America Pharmaceutical, Inc.. The generic name of Rexulti is brexpiprazole. The product's dosage form is tablet and is administered via oral form. The product is distributed in a single package with assigned NDC code ...The half life of Rexulti is 2 weeks, so I didn’t have any withdrawal symptoms until then. The majority of my symptoms were emotional/psych ones. These were my symptoms with the Rexulti: Mood swings and lots of crying, I felt very unstable. Depersonalization and derealization. Severe anxiety.21 Dec 2020 ... problems, medicine withdrawal symptoms, or both of these in your newborn. ... What are possible side effects from using REXULTI? These are not all ...Abilify and Rexulti are both prescription drugs for schizophrenia and major depressive disorder. Learn how their uses, effectiveness, and side effects compare. ... If you have stroke symptoms ... Taking REXULTI during your third trimester of pregnancy may cause your baby to have abnormal muscle movements or withdrawal symptoms after birth. Talk to your healthcare provider about the risk to your unborn baby if you take REXULTI during pregnancy. Taking REXULTI during your third trimester of pregnancy may cause your baby to have abnormal muscle movements or withdrawal symptoms after birth. Talk to your healthcare provider about the risk to your unborn baby if you take REXULTI during pregnancy.6 Jun 2017 ... Research on treating bipolar disorder with Rexulti ... I still dealt with some manic symptoms and possible withdrawal because of the reduction of ...3 Jan 2024 ... Physiological symptoms include runny nose, blurry vision, feelings of fatigue or lethargy, and fever or chills. Some mild neurological symptoms ...May 10, 2023 · Taking REXULTI during your third trimester of pregnancy may cause your baby to have abnormal muscle movements or withdrawal symptoms after birth. Talk to your healthcare provider about the risk to your unborn baby if you take REXULTI during pregnancy. 17 Jun 2022 ... ... withdrawal, lack of energy, emotion, and ... symptoms, hyperprolactinemia, and worsening negative and cognitive symptoms. ... Rexulti (package ...* REXULTI may be administered without dosage adjustment in patients with MDD when administered with strong CYP2D6 inhibitors (e.g., ... May cause extrapyramidal and/or withdrawal symptoms in neonates with third trimester exposure (8.1) See . 17 for PATIENT COUNSELING INFORMATION and Medication Guide. Revised: 12/2021. …Cons. • Can cause weight gain and can raise your blood sugar and blood cholesterol levels. • Must be avoided in older adults who have dementia-related psychosis. • Can raise the risk of suicidal thoughts and behaviors, especially in people who are age 24 or younger. • Need to take immediate-release tablets 2 to 3 times a day.Adding REXULTI reduced mean MÅDRS total score by over 2 points in patients with MDD with or without symptoms of anxiety: For patients with symptoms of anxiety, the LS mean change at Week 6 between ADT + REXULTI 2-3 mg/day and ADT + placebo was -2.19 (95% CI: -3.60 to -0.78) 8..
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